4LTS

Discovery of Potent and Efficacious Cyanoguanidine-containing Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors

Summary for 4LTS

• Entry DOI: 10.2210/pdb4lts/pdb
• Related: 4LWW
• Descriptor: Nicotinamide phosphoribosyltransferase, 2-cyano-1-pyridin-4-yl-3-(4-{[3-(trifluoromethoxy)phenyl]sulfonyl}benzyl)guanidine, PHOSPHATE ION, ... (5 entities in total)
• Functional Keywords: transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus : P43490
• Total number of polymer chains: 2
• Total formula weight: 115584.19

Authors

Zheng, X.,Baumeister, T.,Buckmelter, A.J.,Caligiuri, M.,Clodfelter, K.H.,Han, B.,Ho, Y.,Kley, N.,Lin, J.,Reynoids, D.J.,Sharma, G.,Smith, C.C.,Wang, Z.,Dragovich, P.S.,Oh, A.,Wang, W.,Zak, M.,Wang, L.,Yuen, P.,Bair, K.W. (deposition date: 2013-07-23, release date: 2013-12-25, Last modification date: 2023-09-20)

• Primary citation: Zheng, X.,Baumeister, T.,Buckmelter, A.J.,Caligiuri, M.,Clodfelter, K.H.,Han, B.,Ho, Y.C.,Kley, N.,Lin, J.,Reynolds, D.J.,Sharma, G.,Smith, C.C.,Wang, Z.,Dragovich, P.S.,Oh, A.,Wang, W.,Zak, M.,Wang, Y.,Yuen, P.W.,Bair, K.W.; Discovery of potent and efficacious cyanoguanidine-containing nicotinamide phosphoribosyltransferase (Nampt) inhibitors.; Bioorg.Med.Chem.Lett., 24:337-343, 2014; PubMed: 24279990; DOI: 10.1016/j.bmcl.2013.11.006

Experimental method

X-RAY DIFFRACTION (1.692 Å)