4LS8

Crystal structure of Bacillus subtilis beta-ketoacyl-ACP synthase II (FabF) in a covalent complex with cerulenin

Summary for 4LS8

• Entry DOI: 10.2210/pdb4ls8/pdb
• Related: 4ls5 4ls6 4ls7
• Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase 2, (3R,7E,10E)-3-hydroxy-4-oxododeca-7,10-dienamide, SODIUM ION, ... (6 entities in total)
• Functional Keywords: kasii, ketoacyl synthase, condensing enzyme, fatty acid elongation, cerulenin, drug target, transferase
• Biological source: Bacillus subtilis subsp. subtilis
• Total number of polymer chains: 2
• Total formula weight: 91959.76

Authors

Trajtenberg, F.,Larrieux, N.,Buschiazzo, A. (deposition date: 2013-07-22, release date: 2014-04-02, Last modification date: 2014-06-04)

• Primary citation: Trajtenberg, F.,Altabe, S.,Larrieux, N.,Ficarra, F.,de Mendoza, D.,Buschiazzo, A.,Schujman, G.E.; Structural insights into bacterial resistance to cerulenin.; Febs J., 281:2324-2338, 2014; PubMed: 24641521; DOI: 10.1111/febs.12785

Experimental method

X-RAY DIFFRACTION (2.1 Å)