4LRH

Crystal structure of human folate receptor alpha in complex with folic acid

Replaces:  4KEO

Summary for 4LRH

• Entry DOI: 10.2210/pdb4lrh/pdb
• Descriptor: Folate receptor alpha, FOLIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• Functional Keywords: folate receptor-alpha, folic acid, folate binding protein, cysteine-rich glycoprotein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 8
• Total formula weight: 212748.59

Authors

Ke, J.,Chen, C.,Zhou, X.E.,Yi, W.,Brunzelle, J.S.,Li, J.,Young, E.-L.,Xu, H.E.,Melcher, K. (deposition date: 2013-07-19, release date: 2013-07-31, Last modification date: 2020-07-29)

• Primary citation: Chen, C.,Ke, J.,Zhou, X.E.,Yi, W.,Brunzelle, J.S.,Li, J.,Yong, E.L.,Xu, H.E.,Melcher, K.; Structural basis for molecular recognition of folic acid by folate receptors.; Nature, 500:486-489, 2013; PubMed: 23851396; DOI: 10.1038/nature12327

Experimental method

X-RAY DIFFRACTION (2.8 Å)