4LMQ

Development and Preclinical Characterization of a Humanized Antibody Targeting CXCL12

Summary for 4LMQ

• Entry DOI: 10.2210/pdb4lmq/pdb
• Descriptor: Stromal cell-derived factor 1, hu30D8 Fab heavy chain, hu30D8 Fab light chain, ... (4 entities in total)
• Functional Keywords: immunoglobulin, cell adhesion-immune system complex, cell adhesion/immune system
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted: P48061
• Total number of polymer chains: 6
• Total formula weight: 108211.61

Authors

Zhong, Z.,Wang, J.,Li, B.,Xiang, H.,Ultsch, M.,Coons, M.,Wong, T.,Chiang, N.Y.,Clark, S.,Clark, R.,Quintana, L.,Gribling, P.,Suto, E.,Barck, K.,Corpuz, R.,Yao, J.,Takkar, R.,Lee, W.P.,Damico-Beyer, L.A.,Carano, R.D.,Adams, C.,Kelley, R.F.,Wang, W.,Ferrara, N. (deposition date: 2013-07-10, release date: 2013-08-14, Last modification date: 2021-10-27)

Primary citation

Zhong, C.,Wang, J.,Li, B.,Xiang, H.,Ultsch, M.,Coons, M.,Wong, T.,Chiang, N.Y.,Clark, S.,Clark, R.,Quintana, L.,Gribling, P.,Suto, E.,Barck, K.,Corpuz, R.,Yao, J.,Takkar, R.,Lee, W.P.,Damico-Beyer, L.A.,Carano, R.D.,Adams, C.,Kelley, R.F.,Wang, W.,Ferrara, N.
Development and Preclinical Characterization of a Humanized Antibody Targeting CXCL12.
Clin.Cancer Res., 19:4433-4445, 2013

PubMed Abstract: Our goal was to develop a potent humanized antibody against mouse/human CXCL12. This report summarized its in vitro and in vivo activities.

PubMed: 23812669
DOI: 10.1158/1078-0432.CCR-13-0943

Experimental method

X-RAY DIFFRACTION (2.773 Å)