4LMQ
Development and Preclinical Characterization of a Humanized Antibody Targeting CXCL12
Summary for 4LMQ
Entry DOI | 10.2210/pdb4lmq/pdb |
Descriptor | Stromal cell-derived factor 1, hu30D8 Fab heavy chain, hu30D8 Fab light chain, ... (4 entities in total) |
Functional Keywords | immunoglobulin, cell adhesion-immune system complex, cell adhesion/immune system |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted: P48061 |
Total number of polymer chains | 6 |
Total formula weight | 108211.61 |
Authors | Zhong, Z.,Wang, J.,Li, B.,Xiang, H.,Ultsch, M.,Coons, M.,Wong, T.,Chiang, N.Y.,Clark, S.,Clark, R.,Quintana, L.,Gribling, P.,Suto, E.,Barck, K.,Corpuz, R.,Yao, J.,Takkar, R.,Lee, W.P.,Damico-Beyer, L.A.,Carano, R.D.,Adams, C.,Kelley, R.F.,Wang, W.,Ferrara, N. (deposition date: 2013-07-10, release date: 2013-08-14, Last modification date: 2021-10-27) |
Primary citation | Zhong, C.,Wang, J.,Li, B.,Xiang, H.,Ultsch, M.,Coons, M.,Wong, T.,Chiang, N.Y.,Clark, S.,Clark, R.,Quintana, L.,Gribling, P.,Suto, E.,Barck, K.,Corpuz, R.,Yao, J.,Takkar, R.,Lee, W.P.,Damico-Beyer, L.A.,Carano, R.D.,Adams, C.,Kelley, R.F.,Wang, W.,Ferrara, N. Development and Preclinical Characterization of a Humanized Antibody Targeting CXCL12. Clin.Cancer Res., 19:4433-4445, 2013 Cited by PubMed: 23812669DOI: 10.1158/1078-0432.CCR-13-0943 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.773 Å) |
Structure validation
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