4LLY

Crystal structure of Pertuzumab Clambda Fab with variable and constant domain redesigns (VRD2 and CRD2) at 1.6A

4LLY の概要

• エントリーDOI: 10.2210/pdb4lly/pdb
• 関連するPDBエントリー: 4LLD 4LLM 4LLQ 4LLU 4LLW
• 分子名称: mutated Pertuzumab Fab heavy chain, light chain Clambda, GLYCEROL, ... (5 entities in total)
• 機能のキーワード: fab, immune system
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 94671.85

構造登録者

Pustilnik, A.,Lewis, S.M.,Wu, X.,Sereno, A.,Huang, F.,Guntas, G.,Leaver-Fay, A.,Smith, E.M.,Ho, C.,Hansen-Estruch, C.,Chamberlain, A.K.,Truhlar, S.M.,Kuhlman, B.,Demarest, S.J.,Atwell, S. (登録日: 2013-07-09, 公開日: 2014-01-29, 最終更新日: 2019-06-26)

• 主引用文献: Lewis, S.M.,Wu, X.,Pustilnik, A.,Sereno, A.,Huang, F.,Rick, H.L.,Guntas, G.,Leaver-Fay, A.,Smith, E.M.,Ho, C.,Hansen-Estruch, C.,Chamberlain, A.K.,Truhlar, S.M.,Conner, E.M.,Atwell, S.,Kuhlman, B.,Demarest, S.J.; Generation of bispecific IgG antibodies by structure-based design of an orthogonal Fab interface.; Nat.Biotechnol., 32:191-198, 2014; PubMed: 24463572; DOI: 10.1038/nbt.2797

実験手法

X-RAY DIFFRACTION (1.6 Å)