4LLU

Structure of Pertuzumab Fab with light chain Clambda at 2.16A

Summary for 4LLU

• Entry DOI: 10.2210/pdb4llu/pdb
• Related: 1S78 4LLD 4LLM 4LLQ 4LLW 4LLY
• Descriptor: PERTUZUMAB FAB Heavy chain, Light chain CLAMBDA, SULFATE ION, ... (5 entities in total)
• Functional Keywords: fab, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 94840.63

Authors

Pustilnik, A.,Lewis, S.M.,Wu, X.,Sereno, A.,Huang, F.,Guntas, G.,Leaver-Fay, A.,Smith, E.M.,Ho, C.,Hansen-Estruch, C.,Chamberlain, A.K.,Truhlar, S.M.,Kuhlman, B.,Demarest, S.J.,Atwell, S. (deposition date: 2013-07-09, release date: 2014-01-29, Last modification date: 2023-09-20)

• Primary citation: Lewis, S.M.,Wu, X.,Pustilnik, A.,Sereno, A.,Huang, F.,Rick, H.L.,Guntas, G.,Leaver-Fay, A.,Smith, E.M.,Ho, C.,Hansen-Estruch, C.,Chamberlain, A.K.,Truhlar, S.M.,Conner, E.M.,Atwell, S.,Kuhlman, B.,Demarest, S.J.; Generation of bispecific IgG antibodies by structure-based design of an orthogonal Fab interface.; Nat.Biotechnol., 32:191-198, 2014; PubMed: 24463572; DOI: 10.1038/nbt.2797

Experimental method

X-RAY DIFFRACTION (2.16 Å)