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4LLQ

Structure of redesigned IgG1 first constant and lambda domains (CH1:Clambda constant redesign 2 beta, CRD2b) at 1.42A

Summary for 4LLQ
Entry DOI10.2210/pdb4llq/pdb
Related4LLD 4LLM 4LLU 4LLW 4LLY
Descriptormutated CH1, mutated light chain Clambda, 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, ... (4 entities in total)
Functional Keywordsigg domain redesign, immune system
Biological sourceHomo sapiens (human)
More
Total number of polymer chains2
Total formula weight27962.41
Authors
Primary citationLewis, S.M.,Wu, X.,Pustilnik, A.,Sereno, A.,Huang, F.,Rick, H.L.,Guntas, G.,Leaver-Fay, A.,Smith, E.M.,Ho, C.,Hansen-Estruch, C.,Chamberlain, A.K.,Truhlar, S.M.,Conner, E.M.,Atwell, S.,Kuhlman, B.,Demarest, S.J.
Generation of bispecific IgG antibodies by structure-based design of an orthogonal Fab interface.
Nat.Biotechnol., 32:191-198, 2014
Cited by
PubMed: 24463572
DOI: 10.1038/nbt.2797
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.42 Å)
Structure validation

217705

數據於2024-03-27公開中

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