4LLM

Structure of redesigned IgG1 first constant and lambda domains (CH1:Clambda constant redesign 1, CRD1) at 1.75A

Summary for 4LLM

• Entry DOI: 10.2210/pdb4llm/pdb
• Related: 4LLD 4LLQ 4LLU 4LLW 4LLY
• Descriptor: Ig gamma-1 chain C region, Ig lambda-2 chain C region (3 entities in total)
• Functional Keywords: igg domain, redesign, crd1, immune system
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted : P01857
• Total number of polymer chains: 2
• Total formula weight: 25351.11

Authors

Pustilnik, A.,Lewis, S.M.,Wu, X.,Sereno, A.,Huang, F.,Guntas, G.,Leaver-Fay, A.,Smith, E.M.,Ho, C.,Hansen-Estruch, C.,Chamberlain, A.K.,Truhlar, S.M.,Kuhlman, B.,Demarest, S.J.,Atwell, S. (deposition date: 2013-07-09, release date: 2014-01-29, Last modification date: 2023-09-20)

• Primary citation: Lewis, S.M.,Wu, X.,Pustilnik, A.,Sereno, A.,Huang, F.,Rick, H.L.,Guntas, G.,Leaver-Fay, A.,Smith, E.M.,Ho, C.,Hansen-Estruch, C.,Chamberlain, A.K.,Truhlar, S.M.,Conner, E.M.,Atwell, S.,Kuhlman, B.,Demarest, S.J.; Generation of bispecific IgG antibodies by structure-based design of an orthogonal Fab interface.; Nat.Biotechnol., 32:191-198, 2014; PubMed: 24463572; DOI: 10.1038/nbt.2797

Experimental method

X-RAY DIFFRACTION (1.75 Å)