4LLM
Structure of redesigned IgG1 first constant and lambda domains (CH1:Clambda constant redesign 1, CRD1) at 1.75A
Summary for 4LLM
Entry DOI | 10.2210/pdb4llm/pdb |
Related | 4LLD 4LLQ 4LLU 4LLW 4LLY |
Descriptor | Ig gamma-1 chain C region, Ig lambda-2 chain C region (3 entities in total) |
Functional Keywords | igg domain, redesign, crd1, immune system |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted : P01857 |
Total number of polymer chains | 2 |
Total formula weight | 25351.11 |
Authors | Pustilnik, A.,Lewis, S.M.,Wu, X.,Sereno, A.,Huang, F.,Guntas, G.,Leaver-Fay, A.,Smith, E.M.,Ho, C.,Hansen-Estruch, C.,Chamberlain, A.K.,Truhlar, S.M.,Kuhlman, B.,Demarest, S.J.,Atwell, S. (deposition date: 2013-07-09, release date: 2014-01-29, Last modification date: 2023-09-20) |
Primary citation | Lewis, S.M.,Wu, X.,Pustilnik, A.,Sereno, A.,Huang, F.,Rick, H.L.,Guntas, G.,Leaver-Fay, A.,Smith, E.M.,Ho, C.,Hansen-Estruch, C.,Chamberlain, A.K.,Truhlar, S.M.,Conner, E.M.,Atwell, S.,Kuhlman, B.,Demarest, S.J. Generation of bispecific IgG antibodies by structure-based design of an orthogonal Fab interface. Nat.Biotechnol., 32:191-198, 2014 Cited by PubMed: 24463572DOI: 10.1038/nbt.2797 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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