4LLJ
Crystal structure of PDE10A2 with fragment ZT214
Summary for 4LLJ
| Entry DOI | 10.2210/pdb4llj/pdb |
| Related | 4LKQ 4LLL 4LLP 4LLX 4LM0 4LM1 4LM2 4LM3 4LM4 |
| Descriptor | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, 2H-isoindole-1,3-diamine, NICKEL (II) ION, ... (4 entities in total) |
| Functional Keywords | fragment screening, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
| Biological source | Homo sapiens (human) |
| Cellular location | Cytoplasm: Q9Y233 |
| Total number of polymer chains | 2 |
| Total formula weight | 79340.43 |
| Authors | Sridhar, V.,Badger, J.,Logan, C.,Chie-Leon, B.,Nienaber, V. (deposition date: 2013-07-09, release date: 2014-02-26, Last modification date: 2023-09-20) |
| Primary citation | Recht, M.I.,Sridhar, V.,Badger, J.,Bounaud, P.Y.,Logan, C.,Chie-Leon, B.,Nienaber, V.,Torres, F.E. Identification and Optimization of PDE10A Inhibitors Using Fragment-Based Screening by Nanocalorimetry and X-ray Crystallography. J Biomol Screen, 19:497-507, 2014 Cited by PubMed: 24375910DOI: 10.1177/1087057113516493 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.56 Å) |
Structure validation
Download full validation report
