4LJ3

Crystal structure of the EAL domain of c-di-GMP specific phosphodiesterase YahA in complex with substrate c-di-GMP and Ca++

Summary for 4LJ3

Entry DOI	10.2210/pdb4lj3/pdb
Related	4KIE 4lyk
Descriptor	Cyclic di-GMP phosphodiesterase YahA, 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), CALCIUM ION, ... (6 entities in total)
Functional Keywords	pgpg, phosphodiesterase, tim-barrel, hydrolase
Biological source	Escherichia coli
Total number of polymer chains	2
Total formula weight	64101.03
Authors	Sundriyal, A.,Schirmer, T. (deposition date: 2013-07-04, release date: 2014-01-29, Last modification date: 2023-09-20)
Primary citation	Sundriyal, A.,Massa, C.,Samoray, D.,Zehender, F.,Sharpe, T.,Jenal, U.,Schirmer, T. Inherent Regulation of EAL Domain-catalyzed Hydrolysis of Second Messenger Cyclic di-GMP. J.Biol.Chem., 289:6978-6990, 2014 Cited by PubMed: 24451384 DOI: 10.1074/jbc.M113.516195 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation