4LH7

Crystal structure of a LigA inhibitor

Summary for 4LH7

Entry DOI	10.2210/pdb4lh7/pdb
Related	4LH6
Descriptor	DNA ligase, 4-aminothieno[3,2-c]pyridine-2,7-dicarboxamide, BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE, ... (5 entities in total)
Functional Keywords	protein-inhibitor complex, ligase-ligase inhibitor complex, ligase/ligase inhibitor
Biological source	Enterococcus faecalis
Total number of polymer chains	1
Total formula weight	37479.88
Authors	Boriack-Sjodin, P.A.,Prince, D.B. (deposition date: 2013-06-30, release date: 2013-12-25, Last modification date: 2024-02-28)
Primary citation	Murphy-Benenato, K.,Wang, H.,McGuire, H.M.,Davis, H.E.,Gao, N.,Prince, D.B.,Jahic, H.,Stokes, S.S.,Boriack-Sjodin, P.A. Identification through structure-based methods of a bacterial NAD(+)-dependent DNA ligase inhibitor that avoids known resistance mutations. Bioorg.Med.Chem.Lett., 24:360-366, 2014 Cited by PubMed: 24287382 DOI: 10.1016/j.bmcl.2013.11.007 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation