4LH4

Dual inhibition of HIV-1 replication by Integrase-LEDGF allosteric inhibitors is predominant at post-integration stage during virus production rather than at integration

Summary for 4LH4

• Entry DOI: 10.2210/pdb4lh4/pdb
• Related: 1BHL 4LH5
• Descriptor: Integrase, MAGNESIUM ION (3 entities in total)
• Functional Keywords: integrase, transferase
• Biological source: Human immunodeficiency virus 1
• Total number of polymer chains: 1
• Total formula weight: 20163.95

Authors

Ruff, M.,Levy, N.,Eiler, S. (deposition date: 2013-06-30, release date: 2013-12-25, Last modification date: 2024-10-30)

Primary citation

Le Rouzic, E.,Bonnard, D.,Chasset, S.,Bruneau, J.M.,Chevreuil, F.,Le Strat, F.,Nguyen, J.,Beauvoir, R.,Amadori, C.,Brias, J.,Vomscheid, S.,Eiler, S.,Levy, N.,Delelis, O.,Deprez, E.,Saib, A.,Zamborlini, A.,Emiliani, S.,Ruff, M.,Ledoussal, B.,Moreau, F.,Benarous, R.
Dual inhibition of HIV-1 replication by integrase-LEDGF allosteric inhibitors is predominant at the post-integration stage.
Retrovirology, 10:144-144, 2013

PubMed Abstract: LEDGF/p75 (LEDGF) is the main cellular cofactor of HIV-1 integrase (IN). It acts as a tethering factor for IN, and targets the integration of HIV in actively transcribed gene regions of chromatin. A recently developed class of IN allosteric inhibitors can inhibit the LEDGF-IN interaction.

PubMed: 24261564
DOI: 10.1186/1742-4690-10-144

Experimental method

X-RAY DIFFRACTION (1.8 Å)