4LFV
Crystal structure of human FPPS in complex with YS0470 and two molecules of inorganic phosphate
Summary for 4LFV
Entry DOI | 10.2210/pdb4lfv/pdb |
Related | 4DEM 4H5C 4H5D 4H5E 4LFW |
Descriptor | Farnesyl pyrophosphate synthase, [({4-[4-(propan-2-yloxy)phenyl]pyridin-2-yl}amino)methanediyl]bis(phosphonic acid), PHOSPHATE ION, ... (6 entities in total) |
Functional Keywords | transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P14324 |
Total number of polymer chains | 1 |
Total formula weight | 43845.57 |
Authors | Park, J.,Lin, Y.-S.,Tsantrizos, Y.S.,Berghuis, A.M. (deposition date: 2013-06-27, release date: 2014-03-12, Last modification date: 2023-09-20) |
Primary citation | Park, J.,Lin, Y.S.,Tsantrizos, Y.S.,Berghuis, A.M. Structure of human farnesyl pyrophosphate synthase in complex with an aminopyridine bisphosphonate and two molecules of inorganic phosphate. Acta Crystallogr F Struct Biol Commun, 70:299-304, 2014 Cited by PubMed: 24598914DOI: 10.1107/S2053230X14002106 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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