4LFV

Crystal structure of human FPPS in complex with YS0470 and two molecules of inorganic phosphate

Summary for 4LFV

Entry DOI	10.2210/pdb4lfv/pdb
Related	4DEM 4H5C 4H5D 4H5E 4LFW
Descriptor	Farnesyl pyrophosphate synthase, [({4-[4-(propan-2-yloxy)phenyl]pyridin-2-yl}amino)methanediyl]bis(phosphonic acid), PHOSPHATE ION, ... (6 entities in total)
Functional Keywords	transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P14324
Total number of polymer chains	1
Total formula weight	43845.57
Authors	Park, J.,Lin, Y.-S.,Tsantrizos, Y.S.,Berghuis, A.M. (deposition date: 2013-06-27, release date: 2014-03-12, Last modification date: 2023-09-20)
Primary citation	Park, J.,Lin, Y.S.,Tsantrizos, Y.S.,Berghuis, A.M. Structure of human farnesyl pyrophosphate synthase in complex with an aminopyridine bisphosphonate and two molecules of inorganic phosphate. Acta Crystallogr F Struct Biol Commun, 70:299-304, 2014 Cited by PubMed: 24598914 DOI: 10.1107/S2053230X14002106 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation