4LEQ

tRNA guanine transglycosylase (TGT) in complex with Furanoside-Based lin-Benzoguanine 1

4LEQ の概要

• エントリーDOI: 10.2210/pdb4leq/pdb
• 関連するPDBエントリー: 1PUD 2Z7K 3EOS 4KWO 4LBU
• 分子名称: Queuine tRNA-ribosyltransferase, methyl 6-[6-amino-2-(methylamino)-8-oxo-7,8-dihydro-1H-imidazo[4,5-g]quinazolin-4-yl]-5,6-dideoxy-beta-D-ribo-hexofuranoside, GLYCEROL, ... (6 entities in total)
• 機能のキーワード: tim barrel, glycosyltransferase, zinc-binding, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Zymomonas Mobilis subsp. mobilis
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 43745.27

構造登録者

Ehrmann, F.R.,Heine, A.,Klebe, G. (登録日: 2013-06-26, 公開日: 2014-12-24, 最終更新日: 2023-09-20)

• 主引用文献: Barandun, L.J.,Ehrmann, F.R.,Zimmerli, D.,Immekus, F.,Giroud, M.,Grunenfelder, C.,Schweizer, W.B.,Bernet, B.,Betz, M.,Heine, A.,Klebe, G.,Diederich, F.; Replacement of Water Molecules in a Phosphate Binding Site by Furanoside-Appended lin-Benzoguanine Ligands of tRNA-Guanine Transglycosylase (TGT).; Chemistry, 21:126-135, 2015; PubMed: 25483606; DOI: 10.1002/chem.201405764

実験手法

X-RAY DIFFRACTION (1.405 Å)