4LDS

The inward-facing structure of the glucose transporter from Staphylococcus epidermidis

4LDS の概要

• エントリーDOI: 10.2210/pdb4lds/pdb
• 分子名称: Glucose transporter GlcP (1 entity in total)
• 機能のキーワード: alpha helical transmembrane protein, glucose transporter, major facilitator superfamily, transport protein, membrane protein
• 由来する生物種: Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 96814.95

構造登録者

Choe, J.,Aleshin, A.,Iancu, C.V. (登録日: 2013-06-25, 公開日: 2013-10-16, 最終更新日: 2024-02-28)

主引用文献

Iancu, C.V.,Zamoon, J.,Woo, S.B.,Aleshin, A.,Choe, J.Y.
Crystal structure of a glucose/H+ symporter and its mechanism of action.
Proc.Natl.Acad.Sci.USA, 110:17862-17867, 2013

PubMed Abstract: Glucose transporters are required to bring glucose into cells, where it is an essential energy source and precursor in protein and lipid synthesis. These transporters are involved in important common diseases such as cancer and diabetes. Here, we report the crystal structure of the Staphylococcus epidermidis glucose/H(+) symporter in an inward-facing conformation at 3.2-Å resolution. The Staphylococcus epidermidis glucose/H(+) symporter is homologous to human glucose transporters, is very specific and has high avidity for glucose, and is inhibited by the human glucose transport inhibitors cytochalasin B, phloretin, and forskolin. On the basis of the crystal structure in conjunction with mutagenesis and functional studies, we propose a mechanism for glucose/H(+) symport and discuss the symport mechanism versus facilitated diffusion.

PubMed: 24127585
DOI: 10.1073/pnas.1311485110

実験手法

X-RAY DIFFRACTION (3.2 Å)