4LCM

Simvastatin Synthase (LOVD), from Aspergillus Terreus, LovD9 mutant (simh9014)

Summary for 4LCM

Entry DOI	10.2210/pdb4lcm/pdb
Related	3HL9 3HLB 3HLC 3HLD 3HLE 3HLF 3HLG 4LCL
Descriptor	Transesterase (2 entities in total)
Functional Keywords	laboratory-directed evolution, transesterase, transferase
Biological source	Aspergillus terreus
Total number of polymer chains	4
Total formula weight	189084.03
Authors	Gao, X.,Sawaya, M.R.,Yeates, T.O.,Tang, Y. (deposition date: 2013-06-21, release date: 2014-04-02, Last modification date: 2023-09-20)
Primary citation	Jimenez-Oses, G.,Osuna, S.,Gao, X.,Sawaya, M.R.,Gilson, L.,Collier, S.J.,Huisman, G.W.,Yeates, T.O.,Tang, Y.,Houk, K.N. The role of distant mutations and allosteric regulation on LovD active site dynamics. Nat.Chem.Biol., 10:431-436, 2014 Cited by PubMed: 24727900 DOI: 10.1038/nchembio.1503 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.19 Å)

Structure validation