4LAY

Crystal Structure Analysis of FKBP52, Complex with I63

Summary for 4LAY

Entry DOI	10.2210/pdb4lay/pdb
Related	1Q1C 4LAV 4LAW 4LAX
Descriptor	Peptidyl-prolyl cis-trans isomerase FKBP4, {3-[(1R)-3-(3,4-dimethoxyphenyl)-1-({[(2S)-1-(3,3-dimethyl-2-oxopentanoyl)piperidin-2-yl]carbonyl}oxy)propyl]phenoxy}acetic acid (3 entities in total)
Functional Keywords	fk-506 binding domain, hsp90 cochaperone, immunophilin, peptidyl-prolyl isomerase, protein folding, isomerase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm, cytosol (By similarity): Q02790
Total number of polymer chains	1
Total formula weight	31949.09
Authors	Bracher, A.,Kozany, C.,Haehle, A.,Wild, P.,Zacharias, M.,Hausch, F. (deposition date: 2013-06-20, release date: 2013-08-21, Last modification date: 2023-09-20)
Primary citation	Bracher, A.,Kozany, C.,Hahle, A.,Wild, P.,Zacharias, M.,Hausch, F. Crystal Structures of the Free and Ligand-Bound FK1-FK2 Domain Segment of FKBP52 Reveal a Flexible Inter-Domain Hinge. J.Mol.Biol., 425:4134-4144, 2013 Cited by PubMed: 23933011 DOI: 10.1016/j.jmb.2013.07.041 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation