4LAE
Structure-Based Design of New Dihydrofolate Reductase Antibacterial Agents: 7-(Benzimidazol-1-yl)-2,4-diaminoquinazolines
Summary for 4LAE
Entry DOI | 10.2210/pdb4lae/pdb |
Related | 4LAG 4LAH 4LEK |
Descriptor | Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 7-[5,6-dimethyl-2-(1,3-thiazol-2-yl)-1H-benzimidazol-1-yl]quinazoline-2,4-diamine, ... (4 entities in total) |
Functional Keywords | dhfr, protein-inhibitor complex, folate, nadph, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Staphylococcus aureus |
Total number of polymer chains | 1 |
Total formula weight | 20477.95 |
Authors | Hilgers, M.T. (deposition date: 2013-06-19, release date: 2014-02-19, Last modification date: 2024-02-28) |
Primary citation | Lam, T.,Hilgers, M.T.,Cunningham, M.L.,Kwan, B.P.,Nelson, K.J.,Brown-Driver, V.,Ong, V.,Trzoss, M.,Hough, G.,Shaw, K.J.,Finn, J. Structure-Based Design of New Dihydrofolate Reductase Antibacterial Agents: 7-(Benzimidazol-1-yl)-2,4-diaminoquinazolines. J.Med.Chem., 57:651-668, 2014 Cited by PubMed: 24428639DOI: 10.1021/jm401204g PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.69 Å) |
Structure validation
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