4L98

Crystal structure of the complex of F360L PPARgamma mutant with the ligand LT175

Summary for 4L98

Entry DOI	10.2210/pdb4l98/pdb
Related	3B3K 4L96
Descriptor	Peroxisome proliferator-activated receptor gamma, (2S)-2-(biphenyl-4-yloxy)-3-phenylpropanoic acid (3 entities in total)
Functional Keywords	transcription factor, rxralpha, transcription-transcription inhibitor complex, transcription/transcription inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	63389.68
Authors	Pochetti, G.,Montanari, R.,Consalvi, V.,Chiaraluce, R.,Pasquo, A.,Capelli, D.,Loiodice, F.,Laghezza, A.,Lori, C. (deposition date: 2013-06-18, release date: 2014-06-25, Last modification date: 2023-09-20)
Primary citation	Lori, C.,Pasquo, A.,Montanari, R.,Capelli, D.,Consalvi, V.,Chiaraluce, R.,Cervoni, L.,Loiodice, F.,Laghezza, A.,Aschi, M.,Giorgi, A.,Pochetti, G. Structural basis of the transactivation deficiency of the human PPAR gamma F360L mutant associated with familial partial lipodystrophy. Acta Crystallogr.,Sect.D, 70:1965-1976, 2014 Cited by PubMed: 25004973 DOI: 10.1107/S1399004714009638 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.28 Å)

Structure validation