4L98
Crystal structure of the complex of F360L PPARgamma mutant with the ligand LT175
Summary for 4L98
Entry DOI | 10.2210/pdb4l98/pdb |
Related | 3B3K 4L96 |
Descriptor | Peroxisome proliferator-activated receptor gamma, (2S)-2-(biphenyl-4-yloxy)-3-phenylpropanoic acid (3 entities in total) |
Functional Keywords | transcription factor, rxralpha, transcription-transcription inhibitor complex, transcription/transcription inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 63389.68 |
Authors | Pochetti, G.,Montanari, R.,Consalvi, V.,Chiaraluce, R.,Pasquo, A.,Capelli, D.,Loiodice, F.,Laghezza, A.,Lori, C. (deposition date: 2013-06-18, release date: 2014-06-25, Last modification date: 2023-09-20) |
Primary citation | Lori, C.,Pasquo, A.,Montanari, R.,Capelli, D.,Consalvi, V.,Chiaraluce, R.,Cervoni, L.,Loiodice, F.,Laghezza, A.,Aschi, M.,Giorgi, A.,Pochetti, G. Structural basis of the transactivation deficiency of the human PPAR gamma F360L mutant associated with familial partial lipodystrophy. Acta Crystallogr.,Sect.D, 70:1965-1976, 2014 Cited by PubMed: 25004973DOI: 10.1107/S1399004714009638 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.28 Å) |
Structure validation
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