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4L98

Crystal structure of the complex of F360L PPARgamma mutant with the ligand LT175

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, BPeroxisome proliferator-activated receptor gammapolymer27531376.52UniProt (P37231)
Pfam (PF00104)
In PDB
Homo sapiens (human)PPAR-gamma, Nuclear receptor subfamily 1 group C member 3
2A, B(2S)-2-(biphenyl-4-yloxy)-3-phenylpropanoic acidnon-polymer318.42Chemie (LRG)
3waterwater18.0227Chemie (HOH)
Sequence modifications
A, B: 207 - 477 (UniProt: P37231)
PDBExternal DatabaseDetails
Gly 203-expression tag
Ser 204-expression tag
His 205-expression tag
Met 206-expression tag
Leu 360Phe 388engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight62752.9
Non-Polymers*Number of molecules2
Total formula weight636.7
All*Total formula weight63389.7
*Water molecules are not included.

223790

PDB entries from 2024-08-14

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