4L98
Crystal structure of the complex of F360L PPARgamma mutant with the ligand LT175
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Peroxisome proliferator-activated receptor gamma | polymer | 275 | 31376.5 | 2 | UniProt (P37231) Pfam (PF00104) | Homo sapiens (human) | PPAR-gamma, Nuclear receptor subfamily 1 group C member 3 |
| 2 | C, D (A, B) | (2S)-2-(biphenyl-4-yloxy)-3-phenylpropanoic acid | non-polymer | 318.4 | 2 | Chemie (LRG) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 227 | Chemie (HOH) |
Sequence modifications
A, B: 207 - 477 (UniProt: P37231)
| PDB | External Database | Details |
|---|---|---|
| Gly 203 | - | expression tag |
| Ser 204 | - | expression tag |
| His 205 | - | expression tag |
| Met 206 | - | expression tag |
| Leu 360 | Phe 388 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 62752.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 636.7 | |
| All* | Total formula weight | 63389.7 |
