4L8B

Crystal structure of the H2Db in complex with the NP-N5H peptide

4L8B の概要

• エントリーDOI: 10.2210/pdb4l8b/pdb
• 関連するPDBエントリー: 4HUU 4HUV 4HUW 4HUX 4HV8 4L8C 4L8D
• 分子名称: H-2 class I histocompatibility antigen, D-B alpha chain, Beta-2-microglobulin, NP-N5H peptide, ... (7 entities in total)
• 機能のキーワード: influenza, viral escape, t cell immunity, immune system
• 由来する生物種: Mus musculus (mouse); 詳細
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P01899; Secreted: P01887
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 45501.84

構造登録者

Rossjohn, J.,Gras, S. (登録日: 2013-06-16, 公開日: 2013-10-16, 最終更新日: 2023-09-20)

主引用文献

Valkenburg, S.A.,Quinones-Parra, S.,Gras, S.,Komadina, N.,McVernon, J.,Wang, Z.,Halim, H.,Iannello, P.,Cole, C.,Laurie, K.,Kelso, A.,Rossjohn, J.,Doherty, P.C.,Turner, S.J.,Kedzierska, K.
Acute emergence and reversion of influenza A virus quasispecies within CD8(+) T cell antigenic peptides.
Nat Commun, 4:2663-2663, 2013

PubMed Abstract: Influenza A virus-specific CD8(+) cytotoxic T lymphocytes (CTLs) provide a degree of cross-strain protection that is potentially subverted by mutation. Here we describe the sequential emergence of such variants within CTL epitopes for a persistently infected, immunocompromised infant. Further analysis in immunodeficient and wild-type mice supports the view that CTL escape variants arise frequently in influenza, accumulate with time and revert in the absence of immune pressure under MHCI-mismatched conditions. Viral fitness, the abundance of endogenous CD8(+) T cell responses and T cell receptor repertoire diversity influence the nature of these de novo mutants. Structural characterization of dominant escape variants shows how the peptide-MHCI interaction is modified to affect variant-MHCI stability. The mechanism of influenza virus escape thus looks comparable to that recognized for chronic RNA viruses like HIV and HCV, suggesting that immunocompromised patients with prolonged viral infection could have an important part in the emergence of influenza quasispecies.

PubMed: 24173108
DOI: 10.1038/ncomms3663

実験手法

X-RAY DIFFRACTION (2.2 Å)