4L2X

Crystal structure of human FPPS in complex with magnesium, CL02134, and inorganic pyrophosphate

Summary for 4L2X

Entry DOI	10.2210/pdb4l2x/pdb
Related	4JVJ
Descriptor	Farnesyl pyrophosphate synthase, ({[6-(4-cyclopropylphenyl)thieno[2,3-d]pyrimidin-4-yl]amino}methanediyl)bis(phosphonic acid), PYROPHOSPHATE 2-, ... (5 entities in total)
Functional Keywords	transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P14324
Total number of polymer chains	1
Total formula weight	43835.19
Authors	Park, J.,Leung, C.-Y.,Tsantrizos, Y.S.,Berghuis, A.M. (deposition date: 2013-06-04, release date: 2014-01-01, Last modification date: 2023-09-20)
Primary citation	Leung, C.Y.,Park, J.,De Schutter, J.W.,Sebag, M.,Berghuis, A.M.,Tsantrizos, Y.S. Thienopyrimidine Bisphosphonate (ThPBP) Inhibitors of the Human Farnesyl Pyrophosphate Synthase: Optimization and Characterization of the Mode of Inhibition. J.Med.Chem., 56:7939-7950, 2013 Cited by PubMed: 23998921 DOI: 10.1021/jm400946f PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.55 Å)

Structure validation