4L2H

Structure of a catalytically inactive PARG in complex with a poly-ADP-ribose fragment

4L2H の概要

• エントリーDOI: 10.2210/pdb4l2h/pdb
• 分子名称: Poly(ADP-ribose) glycohydrolase, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE (3 entities in total)
• 機能のキーワード: macrodomain, poly-adp-ribose glycohydrolase, poly-adp-ribose, hydrolase
• 由来する生物種: Tetrahymena thermophila
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 57003.67

構造登録者

Brassington, A.,Dunstan, M.S.,Leys, D. (登録日: 2013-06-04, 公開日: 2013-07-24, 最終更新日: 2023-09-20)

• 主引用文献: Barkauskaite, E.,Brassington, A.,Tan, E.S.,Warwicker, J.,Dunstan, M.S.,Banos, B.,Lafite, P.,Ahel, M.,Mitchison, T.J.,Ahel, I.,Leys, D.; Visualization of poly(ADP-ribose) bound to PARG reveals inherent balance between exo- and endo-glycohydrolase activities.; Nat Commun, 4:2164-2164, 2013; PubMed: 23917065; DOI: 10.1038/ncomms3164

実験手法

X-RAY DIFFRACTION (1.46 Å)