Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

4L26

Crystal structure of DNA duplex containing consecutive T-T mispairs (Br-derivative)

Summary for 4L26
Entry DOI10.2210/pdb4l26/pdb
Related4L24 4L25
DescriptorDNA (5'-D(*CP*GP*(CBR)P*GP*AP*TP*TP*TP*CP*GP*CP*G)-3') (2 entities in total)
Functional Keywordst-t mispair, a-t-t triplet, non-helical dna duplex, dna
Total number of polymer chains2
Total formula weight7466.55
Authors
Kondo, J.,Yamada, T.,Hirose, C.,Tanaka, Y.,Ono, A. (deposition date: 2013-06-04, release date: 2014-03-05, Last modification date: 2024-03-20)
Primary citationKondo, J.,Yamada, T.,Hirose, C.,Okamoto, I.,Tanaka, Y.,Ono, A.
Crystal Structure of Metallo DNA Duplex Containing Consecutive Watson-Crick-like T-Hg(II) -T Base Pairs
Angew.Chem.Int.Ed.Engl., 53:2385-2388, 2014
Cited by
PubMed Abstract: The metallo DNA duplex containing mercury-mediated T-T base pairs is an attractive biomacromolecular nanomaterial which can be applied to nanodevices such as ion sensors. Reported herein is the first crystal structure of a B-form DNA duplex containing two consecutive T-Hg(II)-T base pairs. The Hg(II) ion occupies the center between two T residues. The N3-Hg(II) bond distance is 2.0 Å. The relatively short Hg(II)-Hg(II) distance (3.3 Å) observed in consecutive T-Hg(II)-T base pairs suggests that the metallophilic attraction could exist between them and may stabilize the B-form double helix. To support this, the DNA duplex is largely distorted and adopts an unusual nonhelical conformation in the absence of Hg(II). The structure of the metallo DNA duplex itself and the Hg(II)-induced structural switching from the nonhelical form to the B-form provide the basis for structure-based design of metal-conjugated nucleic acid nanomaterials.
PubMed: 24478025
DOI: 10.1002/anie.201309066
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.4 Å)
Structure validation

227111

PDB entries from 2024-11-06

PDB statisticsPDBj update infoContact PDBjnumon