4L1X
Crystal Structuer of Human 3-alpha Hydroxysteroid Dehydrogenase Type 3 V54L Mutant in Complex with NADP+ and Progesterone
Summary for 4L1X
Entry DOI | 10.2210/pdb4l1x/pdb |
Related | 4L1W |
Descriptor | Aldo-keto reductase family 1 member C2, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, PROGESTERONE, ... (5 entities in total) |
Functional Keywords | alpha-beta barrel, human 3-alpha hsd3, akr, akr1c2, oxidoreductase, aldo-keto reductase, nadph |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm (Potential): P52895 |
Total number of polymer chains | 2 |
Total formula weight | 76248.64 |
Authors | Zhang, B.,Hu, X.-J.,Lin, S.-X. (deposition date: 2013-06-03, release date: 2014-04-16, Last modification date: 2023-11-08) |
Primary citation | Zhang, B.,Zhu, D.-W.,Hu, X.-J.,Zhou, M.,Shang, P.,Lin, S.-X. Human 3-alpha hydroxysteroid dehydrogenase type 3 (3 alpha-HSD3): The V54L mutation restricting the steroid alternative binding and enhancing the 20 alpha-HSD activity J.Steroid Biochem.Mol.Biol., 141:135-143, 2014 Cited by PubMed: 24434280DOI: 10.1016/j.jsbmb.2014.01.003 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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