4L1X
Crystal Structuer of Human 3-alpha Hydroxysteroid Dehydrogenase Type 3 V54L Mutant in Complex with NADP+ and Progesterone
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Aldo-keto reductase family 1 member C2 | polymer | 325 | 36970.4 | 2 | UniProt (P52895) Pfam (PF00248) In PDB | Homo sapiens (human) | 3-alpha-HSD3, Chlordecone reductase homolog HAKRD, Dihydrodiol dehydrogenase 2, DD-2, DD2, Dihydrodiol dehydrogenase/bile acid-binding protein, DD/BABP, Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase, Type III 3-alpha-hydroxysteroid dehydrogenase |
| 2 | A, B | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 2 | Chemie (NAP) | |||
| 3 | A, B | PROGESTERONE | non-polymer | 314.5 | 2 | Chemie (STR) | |||
| 4 | A, B | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 5 | water | water | 18.0 | 544 | Chemie (HOH) |
Sequence modifications
A, B: 2 - 323 (UniProt: P52895)
| PDB | External Database | Details |
|---|---|---|
| Ser -1 | - | expression tag |
| Val 0 | - | expression tag |
| Asp 1 | - | expression tag |
| Leu 54 | Val 54 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 73940.8 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 2307.9 | |
| All* | Total formula weight | 76248.6 |
