4L1X
Crystal Structuer of Human 3-alpha Hydroxysteroid Dehydrogenase Type 3 V54L Mutant in Complex with NADP+ and Progesterone
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Aldo-keto reductase family 1 member C2 | polymer | 325 | 36970.4 | 2 | UniProt (P52895) Pfam (PF00248) | Homo sapiens (human) | 3-alpha-HSD3, Chlordecone reductase homolog HAKRD, Dihydrodiol dehydrogenase 2, DD-2, DD2, Dihydrodiol dehydrogenase/bile acid-binding protein, DD/BABP, Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase, Type III 3-alpha-hydroxysteroid dehydrogenase |
| 2 | C, F (A, B) | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 2 | Chemie (NAP) PubChem (5885) PubChem (46936685) PubChem (71717786) PubChem (4412) PubChem (90473931) PubChem (91972139) PubChem (145946263) PubChem (153311489) PubChem (174001641) PubChem (165382010) | |||
| 3 | D, G (A, B) | PROGESTERONE | non-polymer | 314.5 | 2 | Chemie (STR) PubChem (16219863) PubChem (16401562) PubChem (16757724) PubChem (18635648) PubChem (4920) PubChem (5994) PubChem (92940) PubChem (23615931) PubChem (71200542) PubChem (44135692) PubChem (44275133) PubChem (44279092) PubChem (638017) PubChem (657254) PubChem (1807216) PubChem (1807215) PubChem (1807214) PubChem (54269928) PubChem (1274466) PubChem (57526392) PubChem (58483135) PubChem (58766357) PubChem (58872617) PubChem (5320716) PubChem (70865784) PubChem (70987742) PubChem (70987859) PubChem (6576615) PubChem (7048588) PubChem (7059604) PubChem (7059605) PubChem (7059606) PubChem (7092664) PubChem (7092665) PubChem (7092666) PubChem (9948776) PubChem (1201516) PubChem (11869413) PubChem (11869414) PubChem (11869415) PubChem (11876098) PubChem (11876099) PubChem (11876100) PubChem (12303971) PubChem (12303981) PubChem (12303986) PubChem (12303989) PubChem (12303992) PubChem (6603959) PubChem (7004693) PubChem (117072378) PubChem (118670641) PubChem (11869416) PubChem (144033743) PubChem (123410055) PubChem (12303982) PubChem (12303979) PubChem (129010392) PubChem (134688829) PubChem (135189961) PubChem (135190011) PubChem (135249041) PubChem (142168519) PubChem (142402781) PubChem (145130068) PubChem (170068371) PubChem (163070289) PubChem (163070290) PubChem (163070291) PubChem (163070292) | |||
| 4 | E, H (A, B) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 5 | I, J (A, B) | water | water | 18.0 | 544 | Chemie (HOH) |
Sequence modifications
A, B: 2 - 323 (UniProt: P52895)
| PDB | External Database | Details |
|---|---|---|
| Ser -1 | - | expression tag |
| Val 0 | - | expression tag |
| Asp 1 | - | expression tag |
| Leu 54 | Val 54 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 73940.8 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 2307.9 | |
| All* | Total formula weight | 76248.6 |
