4L1X

Crystal Structuer of Human 3-alpha Hydroxysteroid Dehydrogenase Type 3 V54L Mutant in Complex with NADP+ and Progesterone

4L1X の概要

• エントリーDOI: 10.2210/pdb4l1x/pdb
• 関連するPDBエントリー: 4L1W
• 分子名称: Aldo-keto reductase family 1 member C2, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, PROGESTERONE, ... (5 entities in total)
• 機能のキーワード: alpha-beta barrel, human 3-alpha hsd3, akr, akr1c2, oxidoreductase, aldo-keto reductase, nadph
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm (Potential): P52895
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 76248.64

構造登録者

Zhang, B.,Hu, X.-J.,Lin, S.-X. (登録日: 2013-06-03, 公開日: 2014-04-16, 最終更新日: 2023-11-08)

• 主引用文献: Zhang, B.,Zhu, D.-W.,Hu, X.-J.,Zhou, M.,Shang, P.,Lin, S.-X.; Human 3-alpha hydroxysteroid dehydrogenase type 3 (3 alpha-HSD3): The V54L mutation restricting the steroid alternative binding and enhancing the 20 alpha-HSD activity; J.Steroid Biochem.Mol.Biol., 141:135-143, 2014; PubMed: 24434280; DOI: 10.1016/j.jsbmb.2014.01.003

実験手法

X-RAY DIFFRACTION (2 Å)