4KZ0
Structure of PI3K gamma with Imidazopyridine inhibitors
Summary for 4KZ0
| Entry DOI | 10.2210/pdb4kz0/pdb |
| Related | 4KZC |
| Descriptor | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, methyl 2-(acetylamino)-1,3-benzothiazole-6-carboxylate, SULFATE ION, ... (4 entities in total) |
| Functional Keywords | lipid kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
| Biological source | Homo sapiens (human) |
| Cellular location | Cytoplasm: P48736 |
| Total number of polymer chains | 1 |
| Total formula weight | 111102.50 |
| Authors | Knapp, M.S.,Elling, R.A. (deposition date: 2013-05-29, release date: 2013-07-17, Last modification date: 2024-02-28) |
| Primary citation | Pecchi, S.,Ni, Z.J.,Han, W.,Smith, A.,Lan, J.,Burger, M.,Merritt, H.,Wiesmann, M.,Chan, J.,Kaufman, S.,Knapp, M.S.,Janssen, J.,Huh, K.,Voliva, C.F. Structure guided optimization of a fragment hit to imidazopyridine inhibitors of PI3K. Bioorg.Med.Chem.Lett., 23:4652-4656, 2013 Cited by PubMed: 23820386DOI: 10.1016/j.bmcl.2013.06.010 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.87 Å) |
Structure validation
Download full validation report
