4KXY

Human transketolase in complex with ThDP analogue (R)-2-(1,2-dihydroxyethyl)-3-deaza-ThDP

Summary for 4KXY

• Entry DOI: 10.2210/pdb4kxy/pdb
• Descriptor: Transketolase, 1,2-ETHANEDIOL, CALCIUM ION, ... (7 entities in total)
• Functional Keywords: thiamin diphosphate, enzyme catalysis, pentose phosphate pathway, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 142255.76

Authors

Neumann, P.,Luedtke, S.,Erixon, K.M.,Leeper, F.,Kluger, R.,Ficner, R.,Tittmann, K. (deposition date: 2013-05-28, release date: 2013-08-21, Last modification date: 2023-09-20)

• Primary citation: Ludtke, S.,Neumann, P.,Erixon, K.M.,Leeper, F.,Kluger, R.,Ficner, R.,Tittmann, K.; Sub-angstrom-resolution crystallography reveals physical distortions that enhance reactivity of a covalent enzymatic intermediate.; Nat Chem, 5:762-767, 2013; PubMed: 23965678; DOI: 10.1038/nchem.1728

Experimental method

X-RAY DIFFRACTION (1.26 Å)