4KXY
Human transketolase in complex with ThDP analogue (R)-2-(1,2-dihydroxyethyl)-3-deaza-ThDP
Summary for 4KXY
Entry DOI | 10.2210/pdb4kxy/pdb |
Descriptor | Transketolase, 1,2-ETHANEDIOL, CALCIUM ION, ... (7 entities in total) |
Functional Keywords | thiamin diphosphate, enzyme catalysis, pentose phosphate pathway, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 142255.76 |
Authors | Neumann, P.,Luedtke, S.,Erixon, K.M.,Leeper, F.,Kluger, R.,Ficner, R.,Tittmann, K. (deposition date: 2013-05-28, release date: 2013-08-21, Last modification date: 2023-09-20) |
Primary citation | Ludtke, S.,Neumann, P.,Erixon, K.M.,Leeper, F.,Kluger, R.,Ficner, R.,Tittmann, K. Sub-angstrom-resolution crystallography reveals physical distortions that enhance reactivity of a covalent enzymatic intermediate. Nat Chem, 5:762-767, 2013 Cited by PubMed: 23965678DOI: 10.1038/nchem.1728 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.26 Å) |
Structure validation
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