4KXK

Alanine-glyoxylate aminotransferase variant K390A/K391A in complex with the TPR domain of human Pex5p

Summary for 4KXK

• Entry DOI: 10.2210/pdb4kxk/pdb
• Related: 3R9A 4KYO
• Descriptor: Serine--pyruvate aminotransferase, Peroxisomal targeting signal 1 receptor, SULFATE ION, ... (5 entities in total)
• Functional Keywords: tpr-domain, aminotransferase, pyruvate, transport, peroxisomal import, primary hyperoxaluria, peroxisome, transferase-transport protein complex, transferase/transport protein
• Biological source: Homo sapiens (human); More
• Cellular location: Peroxisome: P21549; Cytoplasm: P50542
• Total number of polymer chains: 4
• Total formula weight: 158681.11

Authors

Fodor, K.,Lou, Y.,Wilmanns, M. (deposition date: 2013-05-27, release date: 2014-11-19, Last modification date: 2023-09-20)

• Primary citation: Fodor, K.,Wolf, J.,Reglinski, K.,Passon, D.M.,Lou, Y.,Schliebs, W.,Erdmann, R.,Wilmanns, M.; Ligand-Induced Compaction of the PEX5 Receptor-Binding Cavity Impacts Protein Import Efficiency into Peroxisomes.; Traffic, 16:85-98, 2015; PubMed: 25369882; DOI: 10.1111/tra.12238

Experimental method

X-RAY DIFFRACTION (2.9 Å)