4KXK

Alanine-glyoxylate aminotransferase variant K390A/K391A in complex with the TPR domain of human Pex5p

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C	Serine--pyruvate aminotransferase	polymer	394	43074.8	2	UniProt (P21549) Pfam (PF00266) In PDB	Homo sapiens (human)	SPT, Alanine--glyoxylate aminotransferase, AGT
2	B, D	Peroxisomal targeting signal 1 receptor	polymer	328	36130.7	2	UniProt (P50542) Pfam (PF13181) In PDB	Homo sapiens (human)	PTS1 receptor, PTS1R, PTS1-BP, Peroxin-5, Peroxisomal C-terminal targeting signal import receptor, Peroxisome receptor 1
3	A, C	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
4	A	BETA-MERCAPTOETHANOL	non-polymer		78.1	1	Chemie (BME)
5		water	water		18.0	40	Chemie (HOH)

Sequence modifications

A, C: 1 - 392 (UniProt: P21549)

PDB	External Database	Details
Gly -1	-	expression tag
Ala 0	-	expression tag
Ala 390	Lys 390	engineered mutation
Ala 391	Lys 391	engineered mutation

B, D: 315 - 639 (UniProt: P50542)

PDB	External Database	Details
Gly 312	-	expression tag
Ala 313	-	expression tag
Met 314	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	158410.9
Non-Polymers*	Number of molecules	3
	Total formula weight	270.3
All*	Total formula weight	158681.1

*Water molecules are not included.