4KWP

Crystal Structure of Human CK2-alpha in complex with a benzimidazole inhibitor (K164) at 1.25 A resolution

Summary for 4KWP

Entry DOI	10.2210/pdb4kwp/pdb
Descriptor	Casein kinase II subunit alpha, SULFATE ION, 1,2-ETHANEDIOL, ... (8 entities in total)
Functional Keywords	kinase, phosphorylation, small molecule inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	41608.54
Authors	Ranchio, A.,Lolli, G.,Battistutta, R. (deposition date: 2013-05-24, release date: 2014-04-09, Last modification date: 2024-02-28)
Primary citation	Cozza, G.,Girardi, C.,Ranchio, A.,Lolli, G.,Sarno, S.,Orzeszko, A.,Kazimierczuk, Z.,Battistutta, R.,Ruzzene, M.,Pinna, L.A. Cell-permeable dual inhibitors of protein kinases CK2 and PIM-1: structural features and pharmacological potential. Cell.Mol.Life Sci., 71:3173-3185, 2014 Cited by PubMed: 24442476 DOI: 10.1007/s00018-013-1552-5 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.25 Å)

Structure validation