4KWG
Crystal Structure Analysis of ALDH2+ALDiB13
Summary for 4KWG
Entry DOI | 10.2210/pdb4kwg/pdb |
Related | 4KWF 4L1O |
Descriptor | Aldehyde dehydrogenase, mitochondrial, 7-bromo-5-methyl-1H-indole-2,3-dione, SODIUM ION, ... (6 entities in total) |
Functional Keywords | aldh2+b13, ketone binding, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Mitochondrion matrix: P05091 |
Total number of polymer chains | 8 |
Total formula weight | 433334.78 |
Authors | Hurley, T.D.,Kimble-Hill, A.C. (deposition date: 2013-05-24, release date: 2014-04-09, Last modification date: 2024-02-28) |
Primary citation | Kimble-Hill, A.C.,Parajuli, B.,Chen, C.H.,Mochly-Rosen, D.,Hurley, T.D. Development of selective inhibitors for aldehyde dehydrogenases based on substituted indole-2,3-diones. J.Med.Chem., 57:714-722, 2014 Cited by PubMed: 24444054DOI: 10.1021/jm401377v PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
Download full validation report