4KTC
NS3/NS4A protease with inhibitor
Summary for 4KTC
Entry DOI | 10.2210/pdb4ktc/pdb |
Related PRD ID | PRD_001133 |
Descriptor | Serine protease NS3, NS4A peptide, ZINC ION, ... (5 entities in total) |
Functional Keywords | protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Hepatitis C virus (isolate Japanese) (HCV) More |
Cellular location | Core protein p21: Host endoplasmic reticulum membrane; Single-pass membrane protein (By similarity). Core protein p19: Virion (By similarity). Envelope glycoprotein E1: Virion membrane; Single-pass type I membrane protein (Potential). Envelope glycoprotein E2: Virion membrane; Single-pass type I membrane protein (Potential). p7: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Protease NS2-3: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Non-structural protein 5A: Host endoplasmic reticulum membrane; Peripheral membrane protein. RNA-directed RNA polymerase: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential): P26662 |
Total number of polymer chains | 4 |
Total formula weight | 45036.56 |
Authors | Zhang, H.,Ballard, J.,Vigers, G.P.A.,Brandhuber, B.J. (deposition date: 2013-05-20, release date: 2013-08-07, Last modification date: 2023-09-20) |
Primary citation | Jiang, Y.,Andrews, S.W.,Condroski, K.R.,Buckman, B.,Serebryany, V.,Wenglowsky, S.,Kennedy, A.L.,Madduru, M.R.,Wang, B.,Lyon, M.,Doherty, G.A.,Woodard, B.T.,Lemieux, C.,Do, M.G.,Zhang, H.,Ballard, J.,Vigers, G.,Brandhuber, B.J.,Stengel, P.,Josey, J.A.,Beigelman, L.,Blatt, L.,Seiwert, S.D. Discovery of Danoprevir (ITMN-191/R7227), a Highly Selective and Potent Inhibitor of Hepatitis C Virus (HCV) NS3/4A Protease. J.Med.Chem., 57:1753-1769, 2014 Cited by PubMed: 23672640DOI: 10.1021/jm400164c PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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