4KS4

Influenza Neuraminidase in complex with antiviral compound (3S,4R,5R)-4-(acetylamino)-3-{4-[(1R)-1-hydroxypropyl]-1H-1,2,3-triazol-1-yl}-5-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid

Summary for 4KS4

Entry DOI	10.2210/pdb4ks4/pdb
Related	4KS1 4KS2 4KS3 4KS5
Descriptor	Neuraminidase, (3S,4R,5R)-4-(acetylamino)-3-{4-[(1R)-1-hydroxypropyl]-1H-1,2,3-triazol-1-yl}-5-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid, CALCIUM ION, ... (4 entities in total)
Functional Keywords	sialidase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Influenza A virus (Influenza Virus)
Cellular location	Host apical cell membrane ; Single-pass type II membrane protein : Q0A480
Total number of polymer chains	1
Total formula weight	43631.21
Authors	Kerry, P.S.,Russell, R.J.M. (deposition date: 2013-05-17, release date: 2013-10-30, Last modification date: 2023-12-27)
Primary citation	Kerry, P.S.,Mohan, S.,Russell, R.J.,Bance, N.,Niikura, M.,Pinto, B.M. Structural basis for a class of nanomolar influenza A neuraminidase inhibitors. Sci Rep, 3:2871-2871, 2013 Cited by PubMed: 24129600 DOI: 10.1038/srep02871 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.495 Å)

Structure validation