4KQF

Crystal structure of CobT E174A complexed with adenine

Summary for 4KQF

Entry DOI	10.2210/pdb4kqf/pdb
Related	1JH8 1L4B 4KQG 4KQH 4KQI 4KQJ 4KQK
Descriptor	Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase, SULFATE ION, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywords	transferase
Biological source	Salmonella enterica subsp. enterica serovar Typhimurium
Total number of polymer chains	1
Total formula weight	36976.85
Authors	Chan, C.H.,Newmister, S.A.,Taylor, K.C.,Claas, K.R.,Rayment, I.,Escalante-Semerena, J.C. (deposition date: 2013-05-15, release date: 2014-03-12, Last modification date: 2024-11-06)
Primary citation	Chan, C.H.,Newmister, S.A.,Talyor, K.,Claas, K.R.,Rayment, I.,Escalante-Semerena, J.C. Dissecting cobamide diversity through structural and functional analyses of the base-activating CobT enzyme of Salmonella enterica. Biochim.Biophys.Acta, 1840:464-475, 2014 Cited by PubMed Abstract: Cobamide diversity arises from the nature of the nucleotide base. Nicotinate mononucleotide (NaMN):base phosphoribosyltransferases (CobT) synthesize α-linked riboside monophosphates from diverse nucleotide base substrates (e.g., benzimidazoles, purines, phenolics) that are incorporated into cobamides. PubMed: 24121107 DOI: 10.1016/j.bbagen.2013.09.038 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation