Summary for 4KQ6
| Entry DOI | 10.2210/pdb4kq6/pdb |
| Descriptor | 6,7-dimethyl-8-ribityllumazine synthase, SULFATE ION, 1-deoxy-1-(6,7-dimethyl-2,4-dioxo-3,4-dihydropteridin-8(2H)-yl)-D-ribitol, ... (5 entities in total) |
| Functional Keywords | lumazine synthase, riboflavin biosynthesis, transferase |
| Biological source | Candida glabrata (Yeast) |
| Total number of polymer chains | 10 |
| Total formula weight | 199162.81 |
| Authors | Shankar, M.,Wilbanks, S.M.,Nakatani, Y.,Monk, B.C.,Tyndall, J.D.A. (deposition date: 2013-05-14, release date: 2013-05-29, Last modification date: 2023-09-20) |
| Primary citation | Shankar, M.,Wilbanks, S.M.,Nakatani, Y.,Monk, B.C.,Tyndall, J.D. Catalysis product captured in lumazine synthase from the fungal pathogen Candida glabrata. Acta Crystallogr.,Sect.D, 69:1580-1586, 2013 Cited by PubMed Abstract: Candida glabrata has emerged as an important fungal pathogen with intrinsic resistance to azole drugs. The limited efficacy of and resistance to existing antifungals is driving the need to identify new drug targets. The enzyme 6,7-dimethyl-8-(D-ribityl)lumazine synthase is part of the riboflavin-biosynthesis pathway essential to fungi and bacteria and is a potential drug target for the development of broad-spectrum antifungal drugs. The X-ray crystal structure of recombinant lumazine synthase from C. glabrata was obtained at 2.24 Å resolution and revealed a dimer of homopentamers, with one in five subunits containing a product molecule from the catalytic reaction. PubMed: 23897480DOI: 10.1107/S0907444913010949 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.24 Å) |
Structure validation
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