4KNW

The crystal structure of human HDHD4 IN COMPLEX WITH MAGNESIUM AND THE PHOSPHATE MIMETIC VANADATE

Summary for 4KNW

• Entry DOI: 10.2210/pdb4knw/pdb
• Related: 4KNV
• Descriptor: N-acylneuraminate-9-phosphatase, VANADATE ION, MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: n-acetylneuraminate, neu5ac-9-phosphate, carbohydrate metabolism, n-acetylneuraminic acid phosphatase, nanp, hdhd4, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 3
• Total formula weight: 86791.34

Authors

Klei, H.E. (deposition date: 2013-05-10, release date: 2013-06-26, Last modification date: 2023-09-20)

• Primary citation: Kim, S.H.,Constantine, K.L.,Duke, G.J.,Goldfarb, V.,Hunt, J.T.,Johnson, S.,Kish, K.,Klei, H.E.,McDonnell, P.A.,Metzler, W.J.,Mueller, L.,Poss, M.A.,Fairchild, C.R.,Bhide, R.S.; Design, synthesis, functional and structural characterization of an inhibitor of N-acetylneuraminate-9-phosphate phosphatase: Observation of extensive dynamics in an enzyme/inhibitor complex.; Bioorg.Med.Chem.Lett., 23:4107-4111, 2013; PubMed: 23747226; DOI: 10.1016/j.bmcl.2013.05.052

Experimental method

X-RAY DIFFRACTION (2.699 Å)