4KNV

The crystal structure of APO HUMAN HDHD4 FROM SE-MAD

4KNV の概要

• エントリーDOI: 10.2210/pdb4knv/pdb
• 関連するPDBエントリー: 4KNW
• 分子名称: N-acylneuraminate-9-phosphatase, PHOSPHATE ION, MAGNESIUM ION, ... (4 entities in total)
• 機能のキーワード: n-acetylneuraminate, neu5ac-9-phosphate, carbohydrate metabolism, n-acetylneuraminic acid phosphatase, nanp, hdhd4, hydrolase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 55132.01

構造登録者

Klei, H.E. (登録日: 2013-05-10, 公開日: 2013-06-26, 最終更新日: 2013-07-10)

• 主引用文献: Kim, S.H.,Constantine, K.L.,Duke, G.J.,Goldfarb, V.,Hunt, J.T.,Johnson, S.,Kish, K.,Klei, H.E.,McDonnell, P.A.,Metzler, W.J.,Mueller, L.,Poss, M.A.,Fairchild, C.R.,Bhide, R.S.; Design, synthesis, functional and structural characterization of an inhibitor of N-acetylneuraminate-9-phosphate phosphatase: Observation of extensive dynamics in an enzyme/inhibitor complex.; Bioorg.Med.Chem.Lett., 23:4107-4111, 2013; PubMed: 23747226; DOI: 10.1016/j.bmcl.2013.05.052

実験手法

X-RAY DIFFRACTION (1.993 Å)