4KM2

Crystal structure of Dihydrofolate reductase from Mycobacterium tuberculosis in an open conformation in complex with trimethoprim

Summary for 4KM2

• Entry DOI: 10.2210/pdb4km2/pdb
• Related: 4KL9 4KLX 4KM0 4KNE
• Descriptor: Dihydrofolate reductase, 2'-MONOPHOSPHOADENOSINE-5'-DIPHOSPHATE, TRIMETHOPRIM, ... (4 entities in total)
• Functional Keywords: reductase, oxidoreductase
• Biological source: Mycobacterium tuberculosis
• Total number of polymer chains: 2
• Total formula weight: 41259.73

Authors

Dias, M.V.B.,Tyrakis, P.,Blundell, T.L. (deposition date: 2013-05-07, release date: 2013-12-25, Last modification date: 2024-02-28)

• Primary citation: Dias, M.V.,Tyrakis, P.,Domingues, R.R.,Paes Leme, A.F.,Blundell, T.L.; Mycobacterium tuberculosis Dihydrofolate Reductase Reveals Two Conformational States and a Possible Low Affinity Mechanism to Antifolate Drugs.; Structure, 22:94-103, 2014; PubMed: 24210757; DOI: 10.1016/j.str.2013.09.022

Experimental method

X-RAY DIFFRACTION (1.4 Å)