4KM2
Crystal structure of Dihydrofolate reductase from Mycobacterium tuberculosis in an open conformation in complex with trimethoprim
Summary for 4KM2
Entry DOI | 10.2210/pdb4km2/pdb |
Related | 4KL9 4KLX 4KM0 4KNE |
Descriptor | Dihydrofolate reductase, 2'-MONOPHOSPHOADENOSINE-5'-DIPHOSPHATE, TRIMETHOPRIM, ... (4 entities in total) |
Functional Keywords | reductase, oxidoreductase |
Biological source | Mycobacterium tuberculosis |
Total number of polymer chains | 2 |
Total formula weight | 41259.73 |
Authors | Dias, M.V.B.,Tyrakis, P.,Blundell, T.L. (deposition date: 2013-05-07, release date: 2013-12-25, Last modification date: 2024-02-28) |
Primary citation | Dias, M.V.,Tyrakis, P.,Domingues, R.R.,Paes Leme, A.F.,Blundell, T.L. Mycobacterium tuberculosis Dihydrofolate Reductase Reveals Two Conformational States and a Possible Low Affinity Mechanism to Antifolate Drugs. Structure, 22:94-103, 2014 Cited by PubMed: 24210757DOI: 10.1016/j.str.2013.09.022 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.4 Å) |
Structure validation
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