4KLX

Crystal structure of dihydrofolate reductase from Mycobacterium tuberculosis in an open conformation.

Summary for 4KLX

Entry DOI	10.2210/pdb4klx/pdb
Related	4KL9 4KM0 4KM2 4KNE
Descriptor	Dihydrofolate reductase, 2'-MONOPHOSPHOADENOSINE-5'-DIPHOSPHATE, 2-{2-[2-2-(METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, ... (4 entities in total)
Functional Keywords	reductase, oxidoreductase
Biological source	Mycobacterium tuberculosis
Total number of polymer chains	2
Total formula weight	40887.34
Authors	Dias, M.V.B.,Tyrakis, P.,Blundell, T.L. (deposition date: 2013-05-07, release date: 2013-12-25, Last modification date: 2024-02-28)
Primary citation	Dias, M.V.,Tyrakis, P.,Domingues, R.R.,Paes Leme, A.F.,Blundell, T.L. Mycobacterium tuberculosis Dihydrofolate Reductase Reveals Two Conformational States and a Possible Low Affinity Mechanism to Antifolate Drugs. Structure, 22:94-103, 2014 Cited by PubMed: 24210757 DOI: 10.1016/j.str.2013.09.022 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.23 Å)

Structure validation