CDK2 in complex with Dinaciclib

Summary for 4KD1

DescriptorCyclin-dependent kinase 2, 1,2-ETHANEDIOL, 3-[({3-ethyl-5-[(2S)-2-(2-hydroxyethyl)piperidin-1-yl]pyrazolo[1,5-a]pyrimidin-7-yl}amino)methyl]-1-hydroxypyridinium, ... (4 entities in total)
Functional Keywordsprotein kinase, dinaciclib, transferase-transferase, cell cycle-inhibitor complex, cell cycle/inhibitor
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm, cytoskeleton, microtubule organizing center, centrosome P24941
Total number of polymer chains1
Total molecular weight34436.05
Martin, M.P.,Schonbrunn, E. (deposition date: 2013-04-24, release date: 2013-09-18, Last modification date: 2013-12-25)
Primary citation
Martin, M.P.,Olesen, S.H.,Georg, G.I.,Schonbrunn, E.
Cyclin-dependent kinase inhibitor dinaciclib interacts with the acetyl-lysine recognition site of bromodomains.
Acs Chem.Biol., 8:2360-2365, 2013
PubMed: 24007471 (PDB entries with the same primary citation)
DOI: 10.1021/cb4003283
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.22660.7%5.7%11.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report