4KC2
Structure of the blood group glycosyltransferase AAglyB in complex with a pyridine inhibitor as a neutral pyrophosphate surrogate
Summary for 4KC2
Entry DOI | 10.2210/pdb4kc2/pdb |
Related | 4KC1 4KC4 |
Descriptor | Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase soluble form, MANGANESE (II) ION, octyl 2-O-(6-deoxy-alpha-L-galactopyranosyl)-beta-D-galactopyranoside, ... (5 entities in total) |
Functional Keywords | gta superfamily, blood group proteins, glycosyltransferase, fuc-gal, udp-gal, udp-galnac, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein: P16442 |
Total number of polymer chains | 1 |
Total formula weight | 34768.94 |
Authors | Cuesta-Seijo, J.A.,Wang, S.,Lafont, D.,Vidal, S.,Palcic, M.M. (deposition date: 2013-04-24, release date: 2013-09-11, Last modification date: 2023-09-20) |
Primary citation | Wang, S.,Cuesta-Seijo, J.A.,Lafont, D.,Palcic, M.M.,Vidal, S. Design of glycosyltransferase inhibitors: pyridine as a pyrophosphate surrogate. Chemistry, 19:15346-15357, 2013 Cited by PubMed: 24108680DOI: 10.1002/chem.201301871 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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