4KC2
Structure of the blood group glycosyltransferase AAglyB in complex with a pyridine inhibitor as a neutral pyrophosphate surrogate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase soluble form | polymer | 290 | 33735.0 | 1 | UniProt (P16442) Pfam (PF03414) | Homo sapiens (human) | Fucosylglycoprotein 3-alpha-galactosyltransferase, Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase, Glycoprotein-fucosylgalactoside alpha-galactosyltransferase, Histo-blood group A transferase, A transferase, Histo-blood group B transferase, B transferase, NAGAT |
| 2 | B (A) | MANGANESE (II) ION | non-polymer | 54.9 | 1 | Chemie (MN) | |||
| 3 | C (A) | octyl 2-O-(6-deoxy-alpha-L-galactopyranosyl)-beta-D-galactopyranoside | non-polymer | 438.5 | 1 | Chemie (BHE) | |||
| 4 | D (A) | 6-(1-beta-D-Galactopyranosyloxymethyl)-N-(5'-deoxyluridine-5'-yl)picolinamide | non-polymer | 540.5 | 1 | Chemie (WS2) | |||
| 5 | E (A) | water | water | 18.0 | 357 | Chemie (HOH) |
Sequence modifications
A: 64 - 346 (UniProt: P16442)
| PDB | External Database | Details |
|---|---|---|
| Met 57 | - | expression tag |
| Ala 58 | - | expression tag |
| Ile 59 | - | expression tag |
| Gly 60 | - | expression tag |
| Glu 61 | - | expression tag |
| Phe 62 | - | expression tag |
| Met 63 | - | expression tag |
| Gly 266 | Leu 266 | SEE REMARK 999 |
| Ala 268 | Gly 268 | SEE REMARK 999 |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 33735.0 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1033.9 | |
| All* | Total formula weight | 34768.9 |
