4KC2

Structure of the blood group glycosyltransferase AAglyB in complex with a pyridine inhibitor as a neutral pyrophosphate surrogate

4KC2 の概要

• エントリーDOI: 10.2210/pdb4kc2/pdb
• 関連するPDBエントリー: 4KC1 4KC4
• 分子名称: Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase soluble form, MANGANESE (II) ION, octyl 2-O-(6-deoxy-alpha-L-galactopyranosyl)-beta-D-galactopyranoside, ... (5 entities in total)
• 機能のキーワード: gta superfamily, blood group proteins, glycosyltransferase, fuc-gal, udp-gal, udp-galnac, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein: P16442
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34768.94

構造登録者

Cuesta-Seijo, J.A.,Wang, S.,Lafont, D.,Vidal, S.,Palcic, M.M. (登録日: 2013-04-24, 公開日: 2013-09-11, 最終更新日: 2023-09-20)

• 主引用文献: Wang, S.,Cuesta-Seijo, J.A.,Lafont, D.,Palcic, M.M.,Vidal, S.; Design of glycosyltransferase inhibitors: pyridine as a pyrophosphate surrogate.; Chemistry, 19:15346-15357, 2013; PubMed: 24108680; DOI: 10.1002/chem.201301871

実験手法

X-RAY DIFFRACTION (1.7 Å)